Pub. Date : 1994 Oct
PMID : 7524464
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Immunohistochemical detection of proliferating cell nuclear antigen (PCNA), a cell cycle-related protein used to estimate tumor growth fraction, is variable in formalin-fixed compared with methanol-fixed tissue specimens. | Formaldehyde | proliferating cell nuclear antigen | Homo sapiens |
| 2 | Immunohistochemical detection of proliferating cell nuclear antigen (PCNA), a cell cycle-related protein used to estimate tumor growth fraction, is variable in formalin-fixed compared with methanol-fixed tissue specimens. | Formaldehyde | proliferating cell nuclear antigen | Homo sapiens |
| 3 | Immunoblotting of formalin fixatives and saline washings after removal of tissue specimens consistently demonstrated the presence of PCNA-like activity in solution. | Formaldehyde | proliferating cell nuclear antigen | Homo sapiens |
| 4 | We conclude that the exceptional solubility of PCNA is responsible for reduced immunostaining in formalin-fixed material, that the loss is irreversible, and that methanol or methacarn is the fixative of choice for PCNA immunohistochemistry. | Formaldehyde | proliferating cell nuclear antigen | Homo sapiens |