Pub. Date : 1994 Aug 30
PMID : 7521167
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HIV coating gp 120 glycoprotein-dependent prostaglandin E2 release by human cultured astrocytoma cells is regulated by nitric oxide formation. | Dinoprostone | inter-alpha-trypsin inhibitor heavy chain 4 | Homo sapiens |
| 2 | The role of the L-arginine-NO pathway on the formation of PGE2 by cultured astroglial cells incubated with the HIV coating glycoprotein gp120 was investigated. | Dinoprostone | inter-alpha-trypsin inhibitor heavy chain 4 | Homo sapiens |
| 3 | Preincubation of human cultured T 67 astrocytoma cells with gp 120 (100-500 nM) produced a significant increase of nitrite (the breakdown product of NO) and PGE2 in cell supernatants. | Dinoprostone | inter-alpha-trypsin inhibitor heavy chain 4 | Homo sapiens |
| 4 | The effect of gp 120 on both nitrite and PGE2 production was antagonized by inhibition of NO synthase by L-NAME (20-300 microM). | Dinoprostone | inter-alpha-trypsin inhibitor heavy chain 4 | Homo sapiens |
| 5 | The inhibition of gp120-induced PGE2 production by L-NAME was reverted by addition of arachidonic acid (30 microM), an effect antagonized by the cyclo-oxygenase inhibitor indomethacin (10 microM). | Dinoprostone | inter-alpha-trypsin inhibitor heavy chain 4 | Homo sapiens |
| 6 | On the basis of present experiments we conclude that gp-120-induced release of PGE2 by astroglial cells is driven by NO, thereby contributing in the involvement of glial cells in HIV-related cerebral disorders. | Dinoprostone | inter-alpha-trypsin inhibitor heavy chain 4 | Homo sapiens |