Title : Protein kinase C and protein kinase A regulate the expression of angiotensin II receptor mRNA in smooth muscle cells.

Pub. Date : 1994 Apr 15

PMID : 7519561






1 Functional Relationships(s)
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1 The maximal decrease (50 +/- 13% of control) occurred at 6 h, followed by a gradual return to the control level within 24 h. H-7 (30 microM), a relatively specific protein kinase C inhibitor, inhibited decrease in the expression of angiotensin II receptor mRNA induced by 6 h angiotensin II treatment, while 6 h stimulation by 0.3 microM phorbol 12-myristate 13-acetate also induced a decrease (35 +/- 8% of control) in the expression of angiotensin II receptor mRNA. Tetradecanoylphorbol Acetate angiotensinogen Rattus norvegicus