Title : Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effects of ionophores on 4'-O-tetrahydropyranyl-adriamycin incorporation in K562 drug-resistant cells.

Pub. Date : 1994 Jul 1

PMID : 7518390






1 Functional Relationships(s)
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1 From our data showing that lipophilic neutral complexes, formed between carboxylic ionophores and metal ions, are both able to inhibit the P-glycoprotein-mediated efflux of anthracycline we can infer that the lipophilicity but not the cationic charge is an important physical property. Metals ATP binding cassette subfamily B member 1 Homo sapiens