Title : Coordinate actions of calcium and protein kinase-C in the expression of primary response genes in pituitary gonadotrophs.

Pub. Date : 1994 Aug

PMID : 7518388






3 Functional Relationships(s)
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1 The agonist-induced expression of PRGs was mimicked by activation of protein kinase-C with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which acted additively with GnRH at low concentrations of both stimuli. Tetradecanoylphorbol Acetate gonadotropin releasing hormone 1 Homo sapiens
2 The agonist-induced expression of PRGs was mimicked by activation of protein kinase-C with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which acted additively with GnRH at low concentrations of both stimuli. Tetradecanoylphorbol Acetate gonadotropin releasing hormone 1 Homo sapiens
3 Depletion of cellular protein kinase-C by prior treatment with PMA reduced GnRH- and PMA-induced expression of PRGs. Tetradecanoylphorbol Acetate gonadotropin releasing hormone 1 Homo sapiens