Title : Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats.

Pub. Date : 1994 May

PMID : 7518301






3 Functional Relationships(s)
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1 In the presence of L-dopa/carbidopa, a peripherally active inhibitor of catechol O-methyltransferase (COMT) entacapone had a short-lasting increasing effect on L-dopa efflux. entacapone catechol-O-methyltransferase Rattus norvegicus
2 In the presence of L-dopa/carbidopa, a peripherally active inhibitor of catechol O-methyltransferase (COMT) entacapone had a short-lasting increasing effect on L-dopa efflux. entacapone catechol-O-methyltransferase Rattus norvegicus
3 Our results demonstrate that entacapone is a peripheral COMT inhibitor and support the view that CGP 18014 is mainly a centrally acting inhibitor of O-methylation. entacapone catechol-O-methyltransferase Rattus norvegicus