| Protein Name | catechol-O-methyltransferase |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24267 |
| Gene Symbol | Comt |
| UniProt | P22734 (COMT_RAT), F2W8B0 (F2W8B0_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
339
Total Number of Articles : 426 |
Description |
catechol-O-methyltransferase |
| Gene Summary |
Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; positive regulation of homocysteine metabolic process; and response to olanzapine. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Is active in glutamatergic synapse and postsynapse. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of skin and connective tissue (multiple); cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |