Pub. Date : 1994 Feb
PMID : 7516359
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Adenosine triphosphate protection of chlordecone-amplified CCl4 hepatotoxicity and lethality. | Adenosine Triphosphate | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 2 | The present study was designed to investigate if direct administration of ATP to rats maintained on the chlordecone diet would result in protection from the hepatotoxic and lethal effects of the chlordecone+CCl4 combination. | Adenosine Triphosphate | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 3 | Without ATP administration all rats died within 72 h, while administration of ATP (100 mg/rat, sc) to chlordecone-pretreated rats at -1, +1, 3, 5, 12, 24 and 36 h of CCl4 injection resulted in 100% survival. | Adenosine Triphosphate | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 4 | Injection of ATP, at -1, +1, 3 and 5 h of CCl4 administration to chlordecone pretreated rats decreased plasma enzyme elevations (alanine and aspartate aminotransferase, sorbitol dehydrogenase) as well as substantially preventing elevation of plasma bilirubin levels at 6, 12 and 24 h. Hepatic ATP levels were also elevated at 6 and 12 h, but not at 24 h.(ABSTRACT TRUNCATED AT 250 WORDS) | Adenosine Triphosphate | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 5 | Injection of ATP, at -1, +1, 3 and 5 h of CCl4 administration to chlordecone pretreated rats decreased plasma enzyme elevations (alanine and aspartate aminotransferase, sorbitol dehydrogenase) as well as substantially preventing elevation of plasma bilirubin levels at 6, 12 and 24 h. Hepatic ATP levels were also elevated at 6 and 12 h, but not at 24 h.(ABSTRACT TRUNCATED AT 250 WORDS) | Adenosine Triphosphate | C-C motif chemokine ligand 4 | Rattus norvegicus |