Pub. Date : 1994 Mar
PMID : 7515983
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory effect of trimetazidine on thrombin-induced aggregation and calcium entry into human platelets. | Trimetazidine | coagulation factor II, thrombin | Homo sapiens |
| 2 | Preincubation with trimetazidine dose-dependently inhibited platelet aggregation induced by 0.05 U/ml thrombin (p < 0.001). | Trimetazidine | coagulation factor II, thrombin | Homo sapiens |
| 3 | In platelets stimulated by 0.05 U/ml thrombin, 0.1 mM trimetazidine did not modify pHi variations but decreased [Ca2+]i variations (p < 0.003, n = 16), blunting by 28 +/- 6% the transient peak of [Ca2+]i (p < 0.006) and decreasing by 6 +/- 2% the equilibrium value (p < 0.005). | Trimetazidine | coagulation factor II, thrombin | Homo sapiens |
| 4 | Trimetazidine therefore attenuates the Ca2+ influx evoked by thrombin, thereby limiting Ca2+ accumulation in stimulated platelets. | Trimetazidine | coagulation factor II, thrombin | Homo sapiens |