Title : Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.

Pub. Date : 1994 May

PMID : 7514190






1 Functional Relationships(s)
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1 Combinations of cytokines, notably IL-1 beta plus IFN-gamma plus TNF-alpha, induced increased expression of inducible NO synthase mRNA after 6 h and resulted in a fivefold increase in medium nitrite accumulation after 48 h. These cytokines did not impair glucose metabolism or insulin release in response to 16.7 mM glucose, but there was an 80% decrease in islet insulin content. Glucose interferon gamma Homo sapiens