Title : Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.

Pub. Date : 1995

PMID : 7494865






1 Functional Relationships(s)
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1 Molecular biology studies show that TCDD inhibited 17 beta-estradiol-induced cathepsin D gene expression by targeted interaction of the nuclear Ah receptor with imperfect dioxin responsive elements strategically located within the estrogen receptor-Sp1 enhancer sequence of this gene. Estradiol aryl hydrocarbon receptor Homo sapiens