Title : Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase.

Pub. Date : 1995 Dec

PMID : 7493016






3 Functional Relationships(s)
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Protein Name
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1 The Sod2 gene for Mn-superoxide dismutase (MnSOD), an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation, was inactivated by homologous recombination. Superoxides superoxide dismutase 2, mitochondrial Mus musculus
2 The Sod2 gene for Mn-superoxide dismutase (MnSOD), an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation, was inactivated by homologous recombination. Superoxides superoxide dismutase 2, mitochondrial Mus musculus
3 These findings indicate that MnSOD is required for normal biological function of tissues by maintaining the integrity of mitochondrial enzymes susceptible to direct inactivation by superoxide. Superoxides superoxide dismutase 2, mitochondrial Mus musculus