Pub. Date : 1978 Nov
PMID : 748014
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | With 1 micrometer tamoxifen, cell growth and PgR induction are suppressed. | Tamoxifen | progesterone receptor | Homo sapiens |
2 | At lower doses (less than 0.1 micrometer), however, tamoxifen is a potent estrogen and rapidly induces (24--48 h) PgR, which increases 4- to 10-fold after 4--6 days and falls if tamoxifen is removed. | Tamoxifen | progesterone receptor | Homo sapiens |
3 | At lower doses (less than 0.1 micrometer), however, tamoxifen is a potent estrogen and rapidly induces (24--48 h) PgR, which increases 4- to 10-fold after 4--6 days and falls if tamoxifen is removed. | Tamoxifen | progesterone receptor | Homo sapiens |
4 | Tamoxifen-induced PgR is similar to that induced by estradiol; it sediments at 8S on sucrose density gradients, is a tight binder (R5020 Kd, 1.7 micrometer at 4 C and 0.87 nM at 15 C), and can be translocated to the nucleus by R5020. | Tamoxifen | progesterone receptor | Homo sapiens |