Title : Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen.

Pub. Date : 1978 Nov

PMID : 748014






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 With 1 micrometer tamoxifen, cell growth and PgR induction are suppressed. Tamoxifen progesterone receptor Homo sapiens
2 At lower doses (less than 0.1 micrometer), however, tamoxifen is a potent estrogen and rapidly induces (24--48 h) PgR, which increases 4- to 10-fold after 4--6 days and falls if tamoxifen is removed. Tamoxifen progesterone receptor Homo sapiens
3 At lower doses (less than 0.1 micrometer), however, tamoxifen is a potent estrogen and rapidly induces (24--48 h) PgR, which increases 4- to 10-fold after 4--6 days and falls if tamoxifen is removed. Tamoxifen progesterone receptor Homo sapiens
4 Tamoxifen-induced PgR is similar to that induced by estradiol; it sediments at 8S on sucrose density gradients, is a tight binder (R5020 Kd, 1.7 micrometer at 4 C and 0.87 nM at 15 C), and can be translocated to the nucleus by R5020. Tamoxifen progesterone receptor Homo sapiens