Pub. Date : 1995 Jun
PMID : 7478679
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The development of morphine tolerance and dependence is associated with translocation of protein kinase C. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 2 | The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 3 | The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 4 | The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 5 | The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 6 | The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 7 | The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 8 | Rats made tolerant to intrathecal administration of morphine showed increased membrane-bound PKC in the superficial layers (laminae I and II) of the spinal cord dorsal horn but not in deeper layers. | Morphine | protein kinase C, gamma | Rattus norvegicus |