Title : Participation of cAMP and cAMP-dependent protein kinase in beta-adrenoceptor-mediated interleukin-1 beta mRNA induction in cultured microglia.

Pub. Date : 1995 Jul

PMID : 7478305






2 Functional Relationships(s)
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1 The present in vitro studies using northern blot analysis showed that the beta-adrenoceptor agonist isoproterenol (1 x 10(-8) to 1 x 10(-5) M) caused a marked induction of IL-1 beta mRNA in microglia, but not in astrocytes. Isoproterenol interleukin 1 beta Rattus norvegicus
2 The induction of IL-1 beta mRNA by either isoproterenol or dbcAMP was strongly inhibited by a cAMP-dependent protein kinase inhibitor, H8. Isoproterenol interleukin 1 beta Rattus norvegicus