Title : Inhibition of protein synthesis blocks the response to 25-hydroxycholesterol by inhibiting degradation of hydroxymethylglutaryl-CoA reductase.

Pub. Date : 1982 Sep 14

PMID : 7126620

1 Functional Relationships(s)
Compound Name
Protein Name
1 The activity of the rate-limiting enzyme of the cholesterol biosynthetic pathway, 3-hydroxy-3-methylglutaryl coenzyme A reductase in Chinese hamster ovary (CHO) cells decreased more rapidly in cells treated with 25-hydroxycholesterol alone (t 1/2 = 1.5 h) than in those incubated with cycloheximide alone (t 1/2 = 5 h). 25-hydroxycholesterol 3-hydroxy-3-methylglutaryl-coenzyme A reductase Cricetulus griseus