CPRiL

4 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	The phenotypic profile of ACR cells chronically exposed to TPA, although effecting a change toward a more transformed phenotype (e.g., growth in agar), was in large measure neither stable nor uniform during consecutive passages or for a given cell strain during different periods of TPA application.	Tetradecanoylphorbol Acetate	acrosin	Homo sapiens
2	The phenotypic profile of ACR cells chronically exposed to TPA, although effecting a change toward a more transformed phenotype (e.g., growth in agar), was in large measure neither stable nor uniform during consecutive passages or for a given cell strain during different periods of TPA application.	Tetradecanoylphorbol Acetate	acrosin	Homo sapiens
3	We speculated that TPA-induced aneuploidy in these cells, coupled with DNA instability and aberrant chromosomal segregation, may conceivably be consistent with neoplasia in initiated ACR cells.	Tetradecanoylphorbol Acetate	acrosin	Homo sapiens
4	Finally, the apparent susceptibility of ACR cells to further transformation by TPA and N-methyl-N1-nitro-N-nitrosoguanidine (MNNG) (34,48) and by ocongenic viruses (37,45) indicates that genetic information residing within these cells, probably in the form of an ACR mutation, renders them more sensitive to these two distinct classes of carcinogens.	Tetradecanoylphorbol Acetate	acrosin	Homo sapiens