Protein Name acrosin
Organism Homo sapiens
Gene ID 49
Gene Symbol


UniProt P10323 (ACRO_HUMAN)
Relationships Total Number of functionally related compound(s) : 454
Total Number of Articles : 352


Gene Summary

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]

  • acrosin
  • acrosin light and heavy chain prepropeptide
  • preproacrosin
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