Pub. Date : 1980 Aug
PMID : 7002082
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydralazine increased the serum renin levels from 3.3 +/- 0.5 to 13.7 +/- 3.1 and 41.9 +/- 2.4 ng/ml/hr at the 1 and 10 mg/kg doses, respectively. | Hydralazine | renin | Rattus norvegicus |
| 2 | Inhibition of hydralazine-induced renin release by indomethacin in the rat. | Hydralazine | renin | Rattus norvegicus |
| 3 | Since the vasodilator hydralazine is thought to stimulate renin release by both of these mechanisms, we examined the effect of indomethacin, a PG synthetase inhibitor, on hydralazine-induced renin release. | Hydralazine | renin | Rattus norvegicus |
| 4 | Since the vasodilator hydralazine is thought to stimulate renin release by both of these mechanisms, we examined the effect of indomethacin, a PG synthetase inhibitor, on hydralazine-induced renin release. | Hydralazine | renin | Rattus norvegicus |
| 5 | Indomethacin inhibited this hydralazine-induced renin release by 100% at the 1 mg/kg dose and 36% at the 10 mg/kg dose even though the hypotensive effect of the drug was unaltered. | Hydralazine | renin | Rattus norvegicus |
| 6 | The beta-blocker, propranolol, was as effective as indomethacin in attenuating hydralazine-induced renin release. | Hydralazine | renin | Rattus norvegicus |
| 7 | Thus, renal PG"s appear to be important as mediators of hydralazine-stimulated renin release but no hydralazine-induced vasodilatation. | Hydralazine | renin | Rattus norvegicus |