Title : Monolayer culture of human fetal and adult pancreas. Static and dynamic studies of insulin release in vitro.

Pub. Date : 1980 Aug

PMID : 6997162






4 Functional Relationships(s)
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1 Caffeine (5 and 10 mM), a phosphodiesterase inhibitor, potentiated insulin release by itself and also induced the glucose-stimulated insulin release from the fetal pancreata in the dose related manner. Caffeine insulin Homo sapiens
2 Caffeine (5 and 10 mM), a phosphodiesterase inhibitor, potentiated insulin release by itself and also induced the glucose-stimulated insulin release from the fetal pancreata in the dose related manner. Caffeine insulin Homo sapiens
3 In the presence of caffeine, the significant increase of insulin release from fetal pancreata was observed with L-leucine, but not with L-arginine. Caffeine insulin Homo sapiens
4 By contrast, glucose (100 and 300 mg/100 ml), tolbutamide (100 microgram/ml), L-arginine (10 mM) and caffeine (5 mM) caused a significant increase of insulin release from adult pancreata. Caffeine insulin Homo sapiens