Pub. Date : 1980
PMID : 6986577
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 5-Hydroxytryptophan (5-HTP) caused a significant increase (p less than 0.05) in arterial plasma renin activity (pra) that was abolished when peripheral and central aromatic amino acid decarboxylase activities were inhibited by administration of benserazide, but not reduced when only the peripheral decarboxylase activities were inhibited by administration of carbidopa. | 5-Hydroxytryptophan | renin | Canis lupus familiaris |
| 2 | 5-Hydroxytryptophan (5-HTP) caused a significant increase (p less than 0.05) in arterial plasma renin activity (pra) that was abolished when peripheral and central aromatic amino acid decarboxylase activities were inhibited by administration of benserazide, but not reduced when only the peripheral decarboxylase activities were inhibited by administration of carbidopa. | 5-Hydroxytryptophan | renin | Canis lupus familiaris |
| 3 | The serotonin receptor blocking drug metergoline also abolished the renin response to 5-HTP. | 5-Hydroxytryptophan | renin | Canis lupus familiaris |
| 4 | These data indicate that 5-HTP and L-Tryptophan act on the central nervous system to produce an increase in renin secretion that is mediated via the renal nerves and occurs without a concomitant increase in sympathetic output to the heart or blood vessels. | 5-Hydroxytryptophan | renin | Canis lupus familiaris |