Pub. Date : 1978 Jun
PMID : 694973
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of the catatoxic steroid, 3beta-hydroxy-20-oxo-5-pregnene-16alpha-carbonitrile [pregnenolone-16alpha-carbonitrile (PCN)] on hepatic microsomal cholesterol-7alpha-hydroxylase, the probable rate-limiting enzyme of bile acide biosynthesis, has been studied. | Pregnenolone Carbonitrile | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 2 | Short term administration (3 days) of PCN in the diet of rats resulted in a significant decrease in the liver microsomal cholesterol-7alpha-hydroxylase activity, in contrast to a marked stimulation of microsomal cytochrome P-450 and ethylmorphine demethylase activity. | Pregnenolone Carbonitrile | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 3 | PCN significantly depressed the cholesterol-7alpha-hydroxylase activity in the livers of rats with elevated levels of the enzyme produced by cholestyramine feeding. | Pregnenolone Carbonitrile | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |