Pub. Date : 1983 Feb
PMID : 6822130
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although the principal actions of clonidine are linked to its centrally mediated suppression of sympathetic activity, its inhibition of the renin axis also may contribute to its antihypertensive effects. | Clonidine | renin | Homo sapiens |
| 2 | In patients with essential hypertension studied in a clinical research center, clonidine-induced decreases in diastolic blood pressure and in plasma renin activity (PRA) correlated closely after one day of treatment, but not thereafter. | Clonidine | renin | Homo sapiens |
| 3 | Moreover, high-renin patients experienced significantly greater blood pressure decrements than low-renin patients during the first day of treatment, but subsequent blood pressure decreases were equal in the two groups, confirming that the sympathoinhibitory action of clonidine is probably independent of the renin-angiotensin system. | Clonidine | renin | Homo sapiens |
| 4 | Thus, clonidine appears to have two separate actions on the renin-aldosterone axis: an early antirenin action primarily in high-renin patients, and a longer-term suppressive effect on aldosterone. | Clonidine | renin | Homo sapiens |
| 5 | Thus, clonidine appears to have two separate actions on the renin-aldosterone axis: an early antirenin action primarily in high-renin patients, and a longer-term suppressive effect on aldosterone. | Clonidine | renin | Homo sapiens |