PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6822130-1	1983	Although the principal actions of clonidine are linked to its centrally mediated suppression of sympathetic activity, its inhibition of the renin axis also may contribute to its antihypertensive effects.	Clonidine	34-43	renin	Homo sapiens	140-145	
6822130-2	1983	In patients with essential hypertension studied in a clinical research center, clonidine-induced decreases in diastolic blood pressure and in plasma renin activity (PRA) correlated closely after one day of treatment, but not thereafter.	Clonidine	79-88	renin	Homo sapiens	149-154	
6822130-3	1983	Moreover, high-renin patients experienced significantly greater blood pressure decrements than low-renin patients during the first day of treatment, but subsequent blood pressure decreases were equal in the two groups, confirming that the sympathoinhibitory action of clonidine is probably independent of the renin-angiotensin system.	Clonidine	268-277	renin	Homo sapiens	15-20	
6822130-7	1983	Thus, clonidine appears to have two separate actions on the renin-aldosterone axis: an early antirenin action primarily in high-renin patients, and a longer-term suppressive effect on aldosterone.	Clonidine	6-15	renin	Homo sapiens	60-65	
6822130-7	1983	Thus, clonidine appears to have two separate actions on the renin-aldosterone axis: an early antirenin action primarily in high-renin patients, and a longer-term suppressive effect on aldosterone.	Clonidine	6-15	renin	Homo sapiens	97-102