Title : Lysophosphatidic acid potentiates the thrombin-induced production of arachidonate metabolites in platelets.

Pub. Date : 1981 Dec 10

PMID : 6795196






3 Functional Relationships(s)
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1 Concentrations (1 to 20 microM) of 1-oleoyl-lysophosphatidic acid which alone do not affect platelet metabolism of arachidonic acid, do augment the effects of suboptimal concentrations of thrombin on the formation of [14C]phosphatidic acid and the production of [14C]arachidonate metabolites from platelets prelabeled with [14C]arachidonate. Carbon-14 coagulation factor II, thrombin Homo sapiens
2 Concentrations (1 to 20 microM) of 1-oleoyl-lysophosphatidic acid which alone do not affect platelet metabolism of arachidonic acid, do augment the effects of suboptimal concentrations of thrombin on the formation of [14C]phosphatidic acid and the production of [14C]arachidonate metabolites from platelets prelabeled with [14C]arachidonate. Carbon-14 coagulation factor II, thrombin Homo sapiens
3 The effect on [14C]phosphatidate occurs with concentrations of thrombin (0.1 unit/ml) which are lower than those (0.2 unit/ml) needed to observe the effects on [14C]arachidonate metabolites. Carbon-14 coagulation factor II, thrombin Homo sapiens