Title : Pyridine nucleotide involvement in rat hepatic drug metabolism: pyridine nucleotide kinetics of aniline parahydroxylation.

Pub. Date : 1980 Oct

PMID : 6786276






2 Functional Relationships(s)
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1 The addition of NADH gave similar stimulation of both aniline parahydroxylation and NADPH-cytochrome P450 reductase activity in the presence of aniline. NAD cytochrome p450 oxidoreductase Rattus norvegicus
2 It is proposed that the increase in aniline metabolism with NADH is due to an increase in the NADPH-cytochrome P450 reductase activity which is rate limiting in microsomes from both phenobarbital and untreated rats. NAD cytochrome p450 oxidoreductase Rattus norvegicus