Title : The effect of vitamin B6 deficiency on alanine: glyoxylate aminotransferase isoenzymes in rat liver.

Pub. Date : 1984 Feb 15

PMID : 6703688






3 Functional Relationships(s)
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1 The effects of vitamin B6 deficiency on hepatic AGT isoenzymes, designated AGT 1 and AGT 2, respectively, were examined with male rats; AGT 1 is located both in the peroxisomes and in the mitochondria, and AGT 2 only in the mitochondria. Vitamin B 6 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens
2 The effects of vitamin B6 deficiency on hepatic AGT isoenzymes, designated AGT 1 and AGT 2, respectively, were examined with male rats; AGT 1 is located both in the peroxisomes and in the mitochondria, and AGT 2 only in the mitochondria. Vitamin B 6 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens
3 The holo activity of combined peroxisomal and mitochondrial AGT 1 with a low Km for L-alanine rapidly decreased after a lag time of about 2 days during feeding of the vitamin B6-deficient diet (by 50% in 5 days, by 86% in 14 days). Vitamin B 6 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens