Title : Regulation of rat liver hydroxymethylglutaryl coenzyme A reductase by a new class of noncompetitive inhibitors. Effects of dichloroacetate and related carboxylic acids on enzyme activity.

Pub. Date : 1983 Nov

PMID : 6630519






1 Functional Relationships(s)
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1 To investigate the mechanism of its cholesterol-lowering action, we studied the effects of DCA and its hepatic metabolites, glyoxylate and oxalate, on the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) obtained from livers of healthy, reverse light-cycled rats. glyoxylic acid 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus