Title : Assembly and breakdown of mammalian protein synthesis initiation complexes: regulation by guanine nucleotides and by phosphorylation of initiation factor eIF-2.

Pub. Date : 1983 Feb 15

PMID : 6551177






2 Functional Relationships(s)
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1 However, if the eIF-2 has previously been phosphorylated by the reticulocyte heme-controlled repressor, the 40S subunit induced inhibition cannot be reversed by elimination of free GDP. Heme eukaryotic translation initiation factor 2 subunit beta Homo sapiens
2 The instability of initiation complexes containing eIF-2, together with the impairment of guanine nucleotide exchange after phosphorylation of eIF-2 [Clemens, M.J., Pain, V.M., Wong, S.-T., & Henshaw, E. C. (1982) Nature (London) 296, 93-95], may be an important aspect of the mechanism of the inhibition of translation by the heme-controlled repressor. Heme eukaryotic translation initiation factor 2 subunit beta Homo sapiens