Title : Synthesis of bridged catechol-homocysteine derivatives as potential inhibitors of catechol O-methyltransferase.

Pub. Date : 1984 Sep

PMID : 6491941






2 Functional Relationships(s)
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1 Synthesis of bridged catechol-homocysteine derivatives as potential inhibitors of catechol O-methyltransferase. Homocysteine catechol-O-methyltransferase Homo sapiens
2 Catechol derivatives, covalently joined to homocysteine by sulfide or sulfonium linkages, were synthesized as potential catechol O-methyltransferase multisubstrate inhibitors which might bridge the enzymatic binding sites for the catechol substrate and the amino acid portion of the methyl donor S-adenosylmethionine. Homocysteine catechol-O-methyltransferase Homo sapiens