Title : Structure-function relationships of human factor VIII complex studied by thioredoxin dependent disulfide reduction.

Pub. Date : 1984 Sep 15

PMID : 6438823






1 Functional Relationships(s)
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1 Limited reduction of disulfide bonds in this complex by NADPH, thioredoxin reductase and thioredoxin leads to partial disaggregation of the multimeric VIII:vWF with concomitant loss of its platelet agglutinating activity in the presence of ristocetin, and with dissociation of factor VIII:C from the complex. Disulfides peroxiredoxin 5 Homo sapiens