Title : Biosynthesis of J-chain in human lymphoid cells producing immunoglobulins of various isotypes.

Pub. Date : 1983 Sep

PMID : 6417475






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In both PWM-stimulated (for 2 days) and unstimulated PBL, equal proportions of free and disulfide-linked J-chain were found. Disulfides joining chain of multimeric IgA and IgM Homo sapiens
2 In tissue culture fluids, J-chain was not secreted in a free form but was always disulfide-linked to polymeric Igs. Disulfides joining chain of multimeric IgA and IgM Homo sapiens
3 In lymphoblastoid cell lines, J-chain was present in a disulfide-linked form in IgM and IGA producers, but in IgG cells and in an IgM cell line (DAUDI) that did not secrete IgM but expressed it on the cell membrane, intracellular J-chain was present in free form. Disulfides joining chain of multimeric IgA and IgM Homo sapiens