Title : Degradation of beta 2-microglobulin in infected urine by leukocyte elastase-like activity.

Pub. Date : 1983 Oct 31

PMID : 6360424






1 Functional Relationships(s)
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1 Evidence that proteolysis of beta 2-microglobulin near neutral pH is due to neutrophil elastase-like activity was obtained by the following methods: use of the model elastase substrate L-pyroglutamyl-L-prolyl-L-valine-p-nitroanilide and the specific inhibitor 2-trifluoroacetylaminobenzenesulphonyl fluoride; use of neutrophil granule extracts and determination of the size distribution of beta 2-microglobulin proteolytic fragments. 2-trifluoroacetylaminobenzenesulphonyl fluoride beta-2-microglobulin Homo sapiens