Title : Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone.

Pub. Date : 1984 Apr

PMID : 6323687






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1 Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone. Morphine pro-opiomelanocortin-alpha Mus musculus
2 The effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on morphine-induced analgesia, tolerance and dependence was investigated by administering alpha-MSH by intracerebroventricular (i.c.v.) Morphine pro-opiomelanocortin-alpha Mus musculus
3 The effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on morphine-induced analgesia, tolerance and dependence was investigated by administering alpha-MSH by intracerebroventricular (i.c.v.) Morphine pro-opiomelanocortin-alpha Mus musculus
4 alpha-MSH antagonized morphine-induced analgesia at doses lower than that necessary to demonstrate hyperalgesia. Morphine pro-opiomelanocortin-alpha Mus musculus
5 Furthermore, the increase in naloxone potency due to morphine pretreatment, which was used as an indicator of tolerance development, was inhibited by alpha-MSH. Morphine pro-opiomelanocortin-alpha Mus musculus
6 The ED50 of naloxone needed to induce withdrawal jumping in dependent mice was increased by alpha-MSH administered 15 min before morphine, but not when alpha-MSH was administered 15 min before naloxone. Morphine pro-opiomelanocortin-alpha Mus musculus
7 These results indicate that alpha-MSH antagonized the actions of morphine but this antagonism did not appear to be mediated through an interaction with opioid receptors. Morphine pro-opiomelanocortin-alpha Mus musculus