Pub. Date : 1984 Apr
PMID : 6323687
7 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone. | Morphine | pro-opiomelanocortin-alpha | Mus musculus | ||
2 | The effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on morphine-induced analgesia, tolerance and dependence was investigated by administering alpha-MSH by intracerebroventricular (i.c.v.) | Morphine | pro-opiomelanocortin-alpha | Mus musculus | ||
3 | The effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on morphine-induced analgesia, tolerance and dependence was investigated by administering alpha-MSH by intracerebroventricular (i.c.v.) | Morphine | pro-opiomelanocortin-alpha | Mus musculus | ||
4 | alpha-MSH antagonized morphine-induced analgesia at doses lower than that necessary to demonstrate hyperalgesia. | Morphine | pro-opiomelanocortin-alpha | Mus musculus | ||
5 | Furthermore, the increase in naloxone potency due to morphine pretreatment, which was used as an indicator of tolerance development, was inhibited by alpha-MSH. | Morphine | pro-opiomelanocortin-alpha | Mus musculus | ||
6 | The ED50 of naloxone needed to induce withdrawal jumping in dependent mice was increased by alpha-MSH administered 15 min before morphine, but not when alpha-MSH was administered 15 min before naloxone. | Morphine | pro-opiomelanocortin-alpha | Mus musculus | ||
7 | These results indicate that alpha-MSH antagonized the actions of morphine but this antagonism did not appear to be mediated through an interaction with opioid receptors. | Morphine | pro-opiomelanocortin-alpha | Mus musculus |