Title : Anti-TSH receptor antibodies in Graves' disease modulate the kinetic behaviour of autologous thyroid TSH receptors. Evidence of the IgG-induced cross-linkage of autologous TSH receptors.

Pub. Date : 1984 Mar

PMID : 6322495






2 Functional Relationships(s)
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1 Analysis of the TSH-TSH receptor interaction in the presence of TSH alone yielded curvilinear Scatchard plots, indicating the existence of two independent classes of binding sites (high affinity Ka: 8.5 +/- 4.8 X 10(8) M-1; low affinity Ka: 5.3 +/- 2.7 X 10(6) M-1). Thyrotropin thyroid stimulating hormone receptor Homo sapiens
2 This marked change in the kinetic behaviour of the TSH binding sites provided evidence that there is a direct interaction between anti-TSH receptor antibodies and autologous TSH receptors. Thyrotropin thyroid stimulating hormone receptor Homo sapiens