Title : Monocyte and granulocyte-mediated tumor cell destruction. A role for the hydrogen peroxide-myeloperoxidase-chloride system.

Pub. Date : 1982 Feb

PMID : 6276438






3 Functional Relationships(s)
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1 In addition, CEM were protected from cytolysis by the effector cells by the myeloperoxidase inhibitors, azide and cyanide, or by performing the experiment under halide-free conditions. 2-chloroethyl methyl sulfide myeloperoxidase Homo sapiens
2 Hypochlorous acid scavengers prevented CEM destruction by the glucose oxidase-myeloperoxidase-chloride system but neither hydroxyl radical nor singlet oxygen scavengers had any protective effect. 2-chloroethyl methyl sulfide myeloperoxidase Homo sapiens
3 Based on these observations we propose that human monocytes or granulocytes can utilize the hydrogen peroxide-myeloperoxidase-chloride system to generate hypochlorous acid or species of similar reactivity as a potential mediator of CEM destruction. 2-chloroethyl methyl sulfide myeloperoxidase Homo sapiens