Title : Selective PF4 release in vitro induced by heparin and related glycosaminoglycans (GAGs)--correlation with beta-TG release and platelet aggregation.

Pub. Date : 1984 Feb 28

PMID : 6202020






9 Functional Relationships(s)
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1 Selective PF4 release in vitro induced by heparin and related glycosaminoglycans (GAGs)--correlation with beta-TG release and platelet aggregation. Glycosaminoglycans platelet factor 4 Homo sapiens
2 Selective PF4 release in vitro induced by heparin and related glycosaminoglycans (GAGs)--correlation with beta-TG release and platelet aggregation. Glycosaminoglycans platelet factor 4 Homo sapiens
3 We studied human platelet aggregation and beta-TG/PF4 release induced by heparin and related GAGs in vitro both in normal PRP and in PRP after aspirin. Glycosaminoglycans platelet factor 4 Homo sapiens
4 In our experimental conditions, heparin and related GAGs always caused PF4 release in vitro from normal platelets, whether or not there was measurable platelet aggregation in the aggregometer. Glycosaminoglycans platelet factor 4 Homo sapiens
5 Therefore, while beta-TG release in vitro seems to correlate with platelet aggregating activity of heparin, the selective PF4 release, caused by heparin and related GAGs also in conditions in which neither platelet aggregation nor beta-TG are measurable, is probably associated with the high affinity of PF4 for heparin. Glycosaminoglycans platelet factor 4 Homo sapiens
6 The degree of affinity of GAGs for PF4 (heparin greater than DeS greater than HS) seems to correlate with PF4 release. Glycosaminoglycans platelet factor 4 Homo sapiens
7 The degree of affinity of GAGs for PF4 (heparin greater than DeS greater than HS) seems to correlate with PF4 release. Glycosaminoglycans platelet factor 4 Homo sapiens
8 Moreover, the significant reduction in PF4 release in vitro after aspirin suggests that GAGs-induced PF4 release is related to a cyclooxygenase-dependent activation process. Glycosaminoglycans platelet factor 4 Homo sapiens
9 Moreover, the significant reduction in PF4 release in vitro after aspirin suggests that GAGs-induced PF4 release is related to a cyclooxygenase-dependent activation process. Glycosaminoglycans platelet factor 4 Homo sapiens