Protein Name platelet factor 4
Organism Homo sapiens
Gene ID 5196
Gene Symbol

PF4

UniProt P02776 (PLF4_HUMAN)
Relationships Total Number of functionally related compound(s) : 276
Total Number of Articles : 703
Description

platelet factor 4

Gene Summary

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

synonyms
  • platelet factor 4
  • C-X-C motif chemokine 4
  • chemokine (C-X-C motif) ligand 4
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Properties