Title : Elucidation of pathways of 5-fluorouracil metabolism in xenografts of human colorectal adenocarcinoma.

Pub. Date : 1983 Jun

PMID : 6191988






1 Functional Relationships(s)
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1 Group 2 tumors demonstrated a lower enzyme ratio (1-2), higher endogenous levels of PRPP, a lower R-1-P/PRPP ratio (1) and appeared to metabolize FUra predominantly by the activity of OPRTase. Phosphoribosyl Pyrophosphate uridine monophosphate synthetase Homo sapiens