| Protein Name | uridine monophosphate synthetase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7372 |
| Gene Symbol | UMPS |
| UniProt | P11172 (UMPS_HUMAN), A8K5J1 (A8K5J1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
114
Total Number of Articles : 182 |
Description |
uridine monophosphate synthetase |
| Gene Summary |
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
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| Properties | |