Pub. Date : 1982
PMID : 6130677
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ninety minutes after a single oral dose of 2 mg prazosin we observed a significant (p less than 0.05) fall in K-value (mean decrease from 1.7 to 1.0), which was accompanied by a blunting of the early insulin response. | Prazosin | insulin | Homo sapiens |
| 2 | It is postulated that the effect of prazosin is mediated by an increase in circulating catecholamines acting on the pancreatic beta-cell alpha 2-adrenoceptors, which are responsible for the well-known inhibitory action of alpha-adrenergic agents upon the release of insulin. | Prazosin | insulin | Homo sapiens |