Title : Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms.

Pub. Date : 1981 Apr

PMID : 6115624






3 Functional Relationships(s)
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1 The epididymal portion of the rat vas deferens from normal and castrated rats exhibited clear differences regarding both the threshold and the maximal response to acetylcholine. Acetylcholine arginine vasopressin Rattus norvegicus
2 Alpha adrenoceptor antagonists, hexamethonium and 6-hydroxydopamine diminished the effectiveness of low acetylcholine concentrations on normal and castrated preparations of the epididymal portion of isolated rat vas deferens, but did not influence the maximal response. Acetylcholine arginine vasopressin Rattus norvegicus
3 The results obtained suggest that low doses of acetylcholine may affect the contractile function of the isolated epididymal portion of rat vas deferens by producing a release of norepinephrine from presynaptic sites and acts in a similar fashion on preparations from both normal and castrated animals. Acetylcholine arginine vasopressin Rattus norvegicus