Title : Studies in vivo on the biosynthesis of collagen and elastin in ascorbic acid-deficient guinea pigs. Evidence for the formation and degradation of a partially hydroxylated collagen.

Pub. Date : 1970 Sep

PMID : 5500318






3 Functional Relationships(s)
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1 After the administration of l-[G-(3)H]proline to guinea pigs deprived of ascorbic acid for increasing periods of time, the specific radioactivities of proline and hydroxyproline in skin collagen and aortic elastin were determined at various time-intervals after administration of the labelled compound with a view to studying the formation and degradation of collagen and elastin both deficient in hydroxyproline. Hydroxyproline elastin Cavia porcellus
2 There was however, a rapid decline in the specific radioactivity of elastin hydroxyproline. Hydroxyproline elastin Cavia porcellus
3 The results suggested that the effect of ascorbic acid deficiency on elastin biosynthesis could be regarded as simply an elimination of hydroxylation of elastin proline with the formation and retention of a polymer increasingly deficient in hydroxyproline. Hydroxyproline elastin Cavia porcellus