Pub. Date : 1979 Aug
PMID : 513503
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reversal of renal cortical actions of angiotensin II by verapamil and manganese. | Verapamil | angiotensinogen | Rattus norvegicus |
| 2 | Despite continued AII infusion, addition of verapamil led to return of values for PGC, QA, Kf, RA, and RE essentially to pre-AII levels. | Verapamil | angiotensinogen | Rattus norvegicus |
| 3 | Since verapamil and manganese are both known to interfere with excitation-contraction coupling of smooth muscle, perhaps by inhibiting transcellular calcium transport, the present results suggest that the calcium ion may be an important cofactor required for the expression of AII action on the glomerular microcirculation, by affecting mesangial and efferent arteriolar smooth muscle contractility. | Verapamil | angiotensinogen | Rattus norvegicus |