Title : [Inhibition of viral reverse transcriptase and leukemogenesis by modified nucleic acids (author's transl)].

Pub. Date : 1975

PMID : 49986






1 Functional Relationships(s)
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1 Partially thiolated polycytidylic acids (MPC I-III, containing 1.7%, 3.5%, and 8.6% 5-mercaptocytidylate units, respectively) inhibited the DNA-polymerase of Friend leukemia virus (FVL) in the endogenic reaction as well as in the presence of poly rA-(dT)14 or poly (dA-dT) templates; the inhibitory activities were directly related to the percent of tholation. Poly C coagulation factor V Homo sapiens