Protein Name coagulation factor V
Organism Homo sapiens
Gene ID 2153
Gene Symbol


UniProt P12259 (FA5_HUMAN)
Relationships Total Number of functionally related compound(s) : 79
Total Number of Articles : 97

coagulation factor V

Gene Summary

This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]

  • coagulation factor V
  • activated protein c cofactor
  • coagulation factor V (proaccelerin, labile factor)
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