Title : Degradation of thyroid hormones by phagocytosing human leukocytes.

Pub. Date : 1973 Jan

PMID : 4629909






3 Functional Relationships(s)
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1 Methimazole stimulates deiodination by MPO and H(2)O(2) but inhibits this reaction when MPO is replaced by lactoperoxidase or horseradish peroxidase.Intact human leukocytes, in the resting state, degrade T(4) and T(3) slowly: degradation, however, is increased markedly during phagocytosis of preopsonized particles. Methimazole myeloperoxidase Homo sapiens
2 Methimazole stimulates deiodination by MPO and H(2)O(2) but inhibits this reaction when MPO is replaced by lactoperoxidase or horseradish peroxidase.Intact human leukocytes, in the resting state, degrade T(4) and T(3) slowly: degradation, however, is increased markedly during phagocytosis of preopsonized particles. Methimazole myeloperoxidase Homo sapiens
3 Methimazole inhibits the formation of iodinated origin material by both normal and MPO-deficient leukocytes. Methimazole myeloperoxidase Homo sapiens