Title : Inactivation of pulmonary NAD+-dependent 15-hydroxyprostaglandin dehydrogenase by acrolein.

Pub. Date : 1985 Dec 15

PMID : 4074386






2 Functional Relationships(s)
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1 Acrolein, a highly reactive aldehyde found in cigarette smoke, was shown to induce time-dependent inactivation of NAD+-linked 15-hydroxyprostaglandin dehydrogenase from porcine lung. NAD carbonyl reductase 1 Homo sapiens
2 Inactivation of pulmonary NAD+-linked 15-hydroxyprostaglandin dehydrogenase by acrolein may alter cellular and circulating thromboxane/prostacyclin ratios and subsequently disturb vascular homeostasis and augment inflammatory and anaphylactic responses in smokers. NAD carbonyl reductase 1 Homo sapiens