Pub. Date : 1985
PMID : 4068748
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this experiment, the intracellular ara-CTP was measured by HPLC after MTX and ara-C were sequentially administered to BDF1 mice bearing L1210 leukemic cell, either being sensitive or resistant to MTX. | Arabinofuranosylcytosine Triphosphate | metaxin 1 | Mus musculus |
| 2 | When MTX at the dose of 12 mg/kg was preceded 6 h and 3 h to ara-C at the dose of 25 mg/kg, the intracellular levels of ara-CTP were found to be significantly higher as compared with those of ara-C alone as control group. | Arabinofuranosylcytosine Triphosphate | metaxin 1 | Mus musculus |
| 3 | At 1 h after ara-C, ara-CTP was measured about 165 and 130% of the control levels, respectively, and at 12 h, ara-CTP was over 4 times higher of control level with group of mice to which MTX was preceded 6 h prior to MTX. | Arabinofuranosylcytosine Triphosphate | metaxin 1 | Mus musculus |
| 4 | At 1 h after ara-C, ara-CTP was measured about 165 and 130% of the control levels, respectively, and at 12 h, ara-CTP was over 4 times higher of control level with group of mice to which MTX was preceded 6 h prior to MTX. | Arabinofuranosylcytosine Triphosphate | metaxin 1 | Mus musculus |
| 5 | On the contrary, the enhancement of ara-CTP production was definitely diminished with MTX-resistant cells in the same administrative model. | Arabinofuranosylcytosine Triphosphate | metaxin 1 | Mus musculus |
| 6 | From our present experiment, the time sequential modulation of intracellular ara-CTP production by MTX was reconfirmed in vivo, and this modulation might depend upon the sensitivity of MTX of leukemic cells. | Arabinofuranosylcytosine Triphosphate | metaxin 1 | Mus musculus |
| 7 | From our present experiment, the time sequential modulation of intracellular ara-CTP production by MTX was reconfirmed in vivo, and this modulation might depend upon the sensitivity of MTX of leukemic cells. | Arabinofuranosylcytosine Triphosphate | metaxin 1 | Mus musculus |