PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 4068748-3 1985 In this experiment, the intracellular ara-CTP was measured by HPLC after MTX and ara-C were sequentially administered to BDF1 mice bearing L1210 leukemic cell, either being sensitive or resistant to MTX. Arabinofuranosylcytosine Triphosphate 38-45 metaxin 1 Mus musculus 73-76 4068748-4 1985 When MTX at the dose of 12 mg/kg was preceded 6 h and 3 h to ara-C at the dose of 25 mg/kg, the intracellular levels of ara-CTP were found to be significantly higher as compared with those of ara-C alone as control group. Arabinofuranosylcytosine Triphosphate 120-127 metaxin 1 Mus musculus 5-8 4068748-5 1985 At 1 h after ara-C, ara-CTP was measured about 165 and 130% of the control levels, respectively, and at 12 h, ara-CTP was over 4 times higher of control level with group of mice to which MTX was preceded 6 h prior to MTX. Arabinofuranosylcytosine Triphosphate 20-27 metaxin 1 Mus musculus 187-190 4068748-5 1985 At 1 h after ara-C, ara-CTP was measured about 165 and 130% of the control levels, respectively, and at 12 h, ara-CTP was over 4 times higher of control level with group of mice to which MTX was preceded 6 h prior to MTX. Arabinofuranosylcytosine Triphosphate 110-117 metaxin 1 Mus musculus 187-190 4068748-6 1985 On the contrary, the enhancement of ara-CTP production was definitely diminished with MTX-resistant cells in the same administrative model. Arabinofuranosylcytosine Triphosphate 36-43 metaxin 1 Mus musculus 86-89 4068748-7 1985 From our present experiment, the time sequential modulation of intracellular ara-CTP production by MTX was reconfirmed in vivo, and this modulation might depend upon the sensitivity of MTX of leukemic cells. Arabinofuranosylcytosine Triphosphate 77-84 metaxin 1 Mus musculus 99-102 4068748-7 1985 From our present experiment, the time sequential modulation of intracellular ara-CTP production by MTX was reconfirmed in vivo, and this modulation might depend upon the sensitivity of MTX of leukemic cells. Arabinofuranosylcytosine Triphosphate 77-84 metaxin 1 Mus musculus 185-188